FLUXestimater

A webserver to estimate cell-/sample-wise metabolic fluxome by using scRNA-seq or general transcriptomics data

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The following resources are provided, including:(1) seven example inputs of scFEA,(2) module information and gene sets of 18 reconstructed metabolic subnetworks in human and mouse,(3) predicted metabolic flux and imputed metabolomic profiles on TCGA, GTEx, CCLE and three example scRNA-seq/snRNA-seq data.

Example input files GSE72056 scRNA-seq example input GSE72056_example.txt
GSE103322 scRNA-seq example input GSE103322_example
Pa03c cell scRNA-seq example input Pa03c.csv
ROSMAP snRNA-seq example input ROSMAP.csv
CCLE example input CCLE.csv
GTEx example input GTEX.csv
TCGA example input TCGA.csv
Module files Module information of the M171 metabolic network in human scFEA.M171.human.moduleinfo.csv
Genes in the M171 metabolic network in human scFEA.M171.human.v1.symbols.gmt
Module information of Glucose-Glutaminolysis metabolic network in human scFEA.Glucose-Glutaminolysis.human.moduleinfo.csv
Genes in Glucose-Glutaminolysis metabolic network in human scFEA.Glucose-Glutaminolysis.human.v1.symbols.gmt
Module information of Glucose-Glutamine metabolic network in human scFEA.Glucose-Glutamine.human.moduleinfo.csv
Genes in Glucose-Glutamine metabolic network in human scFEA.Glucose-Glutamine.human.v1.symbols.gmt
Module information of BCAA metabolic network in human scFEA.BCAA.human.moduleinfo.csv
Genes in BCAA metabolic network in human scFEA.BCAA.human.v1.symbols.gmt
Module information of Acetylcholine metabolic network in human scFEA.Acetylcholine.human.moduleinfo.csv
Genes in Acetylcholine metabolic network in human scFEA.Acetylcholine.human.v1.symbols.gmt
Module information of Dopamine metabolic network in human scFEA.Dopamine.human.moduleinfo.csv
Genes in Dopamine metabolic network in human scFEA.Dopamine.human.v1.symbols.gmt
Module information of Histamine metabolic network in human scFEA.Histamine.human.moduleinfo.csv
Genes in Histamine metabolic network in human scFEA.Histamine.human.v1.symbols.gmt
Module information of Serotonin metabolic network in human scFEA.Serotonin.human.moduleinfo.csv
Genes in Serotonin metabolic network in human scFEA.Serotonin.human.v1.symbols.gmt
Module information of IronIon metabolic network in human scFEA.IronIon.human.moduleinfo.csv
Genes in IronIon metabolic network in human scFEA.IronIon.human.v1.symbols.gmt
Module information of the M171 metabolic network in mouse scFEA.M171.mouse.moduleinfo.csv
Genes in the M171 metabolic network in mouse scFEA.M171.mouse.v1.symbols.gmt
Module information of Glucose-Glutaminolysis metabolic network in mouse scFEA.Glucose-Glutaminolysis.mouse.moduleinfo.csv
Genes in Glucose-Glutaminolysis metabolic network in mouse scFEA.Glucose-Glutaminolysis.mouse.v1.symbols.gmt
Module information of Glucose-Glutamine metabolic network in mouse scFEA.Glucose-Glutamine.mouse.moduleinfo.csv
Genes in Glucose-Glutamine metabolic network in mouse scFEA.Glucose-Glutamine.mouse.v1.symbols.gmt
Module information of BCAA metabolic network in mouse scFEA.BCAA.mouse.moduleinfo.csv
Genes in BCAA metabolic network in mouse scFEA.BCAA.mouse.v1.symbols.gmt
Module information of Acetylcholine metabolic network in mouse scFEA.Acetylcholine.mouse.moduleinfo.csv
Genes in Acetylcholine metabolic network in mouse scFEA.Acetylcholine.mouse.v1.symbols.gmt
Module information of Dopamine metabolic network in mouse scFEA.Dopamine.mouse.moduleinfo.csv
Genes in Dopamine metabolic network in mouse scFEA.Dopamine.mouse.v1.symbols.gmt
Module information of Histamine metabolic network in mouse scFEA.Histamine.mouse.moduleinfo.csv
Genes in Histamine metabolic network in mouse scFEA.Histamine.mouse.v1.symbols.gmt
Module information of Serotonin metabolic network in mouse scFEA.Serotonin.mouse.moduleinfo.csv
Genes in Serotonin metabolic network in mouse scFEA.Serotonin.mouse.v1.symbols.gmt
Module information of IronIon metabolic network in mouse scFEA.IronIon.mouse.moduleinfo.csv
Genes in IronIon metabolic network in mouse scFEA.IronIon.mouse.v1.symbols.gmt
scFEA human genes scFEA.human.genes.txt
scFEA mouse genes scFEA.mouse.genes.txt
Results derived from commonly unilized data sets Predict flux of modules in human M171 network of CCLE data CCLE data flux.csv
Imputed metabolomics profile of metabolites in human M171 network of CCLE data CCLE data imputed metabolomics profile.csv
Predict flux of modules in human M171 network of GTEx data GTEX data flux.csv
Imputed metabolomics profile of metabolites in human M171 network of GTEx data GTEX data imputed metabolomics profile.csv
Predict flux of modules in human M171 network of TCGA data TCGA data flux.csv
Imputed metabolomics profile of metabolites in human M171 network of TCGA data TCGA data imputed metabolomics profile.csv
Results drvived from selected scRNA-seq data sets Predict flux of modules in human M171 network of GSE72056 data GSE72056 flux.csv
Imputed metabolomics profile of metabolites in human M171 network of GSE72056 data GSE72056 imputed metabolomics profile.csv
Predict flux of modules in human M171 network of GSE103322 data GSE103322 flux.csv
Imputed metabolomics profile of metabolites in human M171 network of GSE103322 data GSE103322 imputed metabolomics profile.csv
Predict flux of modules in human M171 network of ROSMAP snRNA-seq data ROSMAP brain scRNA-seq data flux.csv
Imputed metabolomics profile of metabolites in human M171 network of ROSMAP snRNA-seq data ROSMAP brain scRNA-seq data imputed metabolomics profile.csv