Homo sapiens M171
M171:This is the central metabolic map of human. This metabolic network covers the metabolism, transport, and biosynthesis of carbohydrate, amino acids, fatty acids and lipids, glycan, and nucleic acids in human, including 663 genes of 395 enzymes, 1381 reactions, 1468 metabolites, and 116 transporter genes of 35 metabolites in human collected from KEGG and other literatures. After the network simplification, we have simplified and reconstructed this network into 171 modules belong to 22 super module classes and 70 metabolites, out of which 66 are intermediate substrates. We recommend this network for a general characterization of metabolic landscapes.
The 22 super module classes cover glycolysis and TCA cycle, serine and related amino acids metabolism, pentose phosphate, fatty acids biosynthesis/metabolism, aspartate and related amino acids metabolism, beta-alanie metabolism, propanoyl-CoA metabolism, glutamate, glutamine and related amino acids metabolism, leucine and valine and isoleucine (branched chain amin acids) metabolism, urea cycle, spermine metabolism, transporters, hyaluronic acid synthesis, glycogen synthesis, N-linked glycan synthesis, O-linked glycan synthesis, sialic acid synthesis, chondroitin sulfate, dermatan sulfate, heparan sulfate and other glycosaminoglycan biosynthesis, purine synthesis, pyrimidine synthesis, and steroid hormone synthesis.
The figure below illustrates the reconstructed network and super modules. Complete information of the reconstructed network is available in the downloads.